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Aims: To investigate misoprostol use as a self-administered medical abortifacient and to explore the knowledge and availability of misoprostol and attitudes towards it among Saudi women.
Methods: A questionnaire-based cross-sectional study was conducted in obstetric and gynecological outpatient clinics at private and teaching institutions between January 1 and June 29, 2012.
Results: Of the 678 respondents, 40% (271/678) were aware of misoprostol use as an abortifacient and 7.4% (50/678) reported personal use of it as an abortifacient. Misoprostol users were more likely to have had previous abortions (96%, 48/50; p < 0.01), had a relative/friend working in the medical field (70%, 35/50; p < 0.01) and known someone else who had used the drug (82%, 41/50; p < 0.01). The majority responded incorrectly that higher misoprostol doses are required with more advanced gestational age (96%, 48/50) and that misoprostol use confers no fetal risks (100%, 50/50).
Conclusion: The proportion that reported personal use of misoprostol in the current study (7.4%) exceeded that in similar samples in Brazil (2.2%) and the USA (5%). One concerning finding was the users' poor knowledge about misoprostol. Increased awareness about the inherent risks associated with unsupervised misoprostol use as an abortifacient is needed.
© 2014 S. Karger AG, Basel.
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MeSH terms
Abortifacient Agents, Nonsteroidal*
Abortion, Induced / methods*
Adolescent
Adult
Cross-Sectional Studies
Female
Gestational Age
Health Education
Health Knowledge, Attitudes, Practice
Humans
Middle Aged
Misoprostol / administration & dosage*
Pregnancy
Saudi Arabia
Self Medication* / adverse effects
Surveys and Questionnaires
Young Adult
Substances
Abortifacient Agents, Nonsteroidal
Misoprostol
Related information
PubChem Compound (MeSH Keyword)
LinkOut - more resources
Full Text Sources
S. Karger AG, Basel, Switzerland
Other Literature Sources
scite Smart Citations
Miscellaneous
NCI CPTAC Assay Portal
Uses
This medication is used to prevent stomach ulcers while you take NSAIDs (e.g., aspirin, ibuprofen, naproxen), especially if you are at risk for developing ulcers or have a history of ulcers. Misoprostol helps to decrease your risk of serious ulcer complications such as bleeding. This medication protects your stomach lining by lowering the amount of acid that comes in contact with it.This medication is also used in combination with another drug (mifepristone) to end a pregnancy (abortion).
How to use Misoprostol
This medicine comes with a patient information leaflet. Read it carefully. If you have any questions about this drug, ask your doctor, nurse, or pharmacist.
Dosage is based on your medical condition and response to therapy.
If you are taking this drug to prevent stomach ulcers, take it by mouth usually four times a day, after meals and at bedtime to minimize diarrhea, or as directed by your doctor.
If you are taking this medication for abortion, take it by mouth exactly as directed by your doctor.
If you are using this medication to start labor, your healthcare professional will insert it into your vagina.
Avoid taking antacids that contain magnesium while using misoprostol because they may make the diarrhea it causes worse. If you need an antacid, consult your doctor or pharmacist to help you choose a product.
For ulcer prevention, continue to take this drug for as long as you take NSAIDs. Use this medication regularly in order to get the most benefit from it. Remember to use it at the same times each day.
Inform your doctor if your condition persists or worsens.
How does the abortion pill work?
In This Section
The Abortion Pill
How does the abortion pill work?
What can I expect after I take the abortion pill?
How safe is the abortion pill?
How do I get the abortion pill?
The abortion pill causes cramping and bleeding that can last several hours or more. You can be at home, or wherever is comfortable for you. Plan on taking it easy for the day.
Thinking about getting the abortion pill?
FIND A HEALTH CENTER
What do I need to do before I take the abortion pill?
Before you take the abortion pill, you’ll meet with your nurse, doctor, or health center staff to talk about whether abortion is the right decision for you, and what your abortion options are. You’ll get an exam and lab tests, and you may get an ultrasound to figure out how far into your pregnancy you are.
Your nurse or doctor will let you know if there’s anything else you need to do to prepare for your abortion. They’ll give you written instructions on how to take your pills. You will have access to a caring professional through the process — you’ll get a number you can call 24/7 if you have any questions or concerns.
You’ll have a lot of bleeding and cramping after you take the second medicine, so plan ahead to make the process more comfortable. You can be at home, or wherever is comfortable for you to rest. You may also want to have someone you trust with you (or nearby) that you can call for support if you need anything.
Stock up on maxi pads, food, books, movies, or whatever you like to help pass the time, and a heating pad for cramps. Make sure you have some pain medicine — but don’t take aspirin because it can make you bleed more.
What happens during a medication abortion?
The abortion pill process has several steps and includes two different medicines.
First, you take a pill called mifepristone. This medicine stops the pregnancy from growing. Some people feel nauseous or start bleeding after taking mifepristone, but it’s not common. Your doctor or nurse may also give you antibiotics to take to prevent infection.
The second medicine is called misoprostol. You’ll either take the misoprostol right away, or up to 48 hours after you take the first pill — your doctor or nurse will let you know how and when to take it. This medicine causes cramping and bleeding to empty your uterus.
For most people, the cramping and bleeding usually starts 1-4 hours after taking the misoprostol. It’s normal to see large blood clots (up to the size of a lemon) or clumps of tissue when this is happening. It’s kind of like having a really heavy, crampy period, and the process is very similar to an early miscarriage. (If you don’t have any bleeding within 24 hours after taking the second medicine, misoprostol, call your nurse or doctor.)
The cramping and bleeding can last for several hours. Most people finish passing the pregnancy tissue in 4-5 hours, but it may take longer. The cramping and bleeding slows down after the pregnancy tissue comes out. You may have cramping on and off for 1 or 2 more days.
You can take pain medicine like ibuprofen about 30 minutes before you take the second medicine, misoprostol, to help with cramps. You can also take anti-nausea medicine if your doctor or nurse gives it to you. Don’t take aspirin, because it can make you bleed more.
It’s normal to have some bleeding and spotting for several weeks after your abortion. You can use pads, tampons, or a menstrual cup — whatever's the most comfortable for you. But your nurse or doctor may recommend you use pads for the first few days after the abortion so you can track how much you're bleeding.
The last step is a follow up with your nurse or doctor. You may go back into the health center for an ultrasound or blood test. Or you’ll get a pregnancy test to take at home, followed by a phone call with your nurse or doctor. These tests will make sure the abortion worked and that you’re healthy.
In the unlikely case that the abortion doesn't work and you're still pregnant, your doctor or nurse will discuss your options with you. You may need another dose of medication or to have an in-clinic procedure to complete the abortion.
How does a medication abortion feel?
For most people, medication abortion feels like having an early miscarriage. You might have:
lots of cramping and aches in your belly
very heavy bleeding with large clots (If you don’t have any bleeding within 24 hours after taking the second medicine, misoprostol, call your nurse or doctor.)
an upset stomach and vomiting (Your doctor or nurse may give you medicine to help with nausea.)
diarrhea
dizziness
tiredness
mild fever (99-100° F) or chills on the day you take the misoprostol (If you have a fever after the day you take the misoprostol pills, call your doctor or health center right away.)
To help ease pain and make you more comfortable, you can:
Take pain medication like ibuprofen (Advil or Motrin). Don’t take aspirin because it can make your bleeding worse.
Put a heating pad or hot water bottle on your belly.
Take a shower.
Sit on the toilet.
Have someone rub your back.
Misoprostol
Generic name: misoprostol (mye so PRAH stole)
Brand name: Cytotec
Dosage forms: oral tablet (100 mcg; 200 mcg)
Drug class: Miscellaneous GI agents
Medically reviewed by Drugs.com on Jun 30, 2021. Written by Cerner Multum.
Uses
Warnings
Dosage
What to avoid
Side effects
Interactions
What is misoprostol?
Misoprostol reduces stomach acid and helps protect the stomach from damage that can be caused by taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.
Misoprostol is used to prevent stomach ulcers during treatment with aspirin or an NSAID.
Misoprostol may also be used for purposes not listed in this medication guide.
Warnings
Misoprostol can cause birth defects, premature birth, uterine rupture, miscarriage, or incomplete miscarriage and dangerous uterine bleeding. Do not use misoprostol if you are pregnant.
If you are able to b